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Professor Luiz Carlos Dias

 

Prof. Dr. Luiz Carlos Dias
Professor. Luiz Carlos Dias

Luiz Carlos Dias

Associate Professor – MS-5

Instituto de Química – UNICAMP

C.P. 6154, 13084-971, Campinas, SP, Brazil

Phone: +55-19-3521-3097

e-mail: ldias@iqm.unicamp.br

Prof. Luiz C. Dias was born in Balneário de Camboriú, SC, Brazil. He studied Chemistry at the Federal University of Santa Catarina, UFSC (B.Sc., 1988) and finished his Ph.D. in 1993, at The State University of Campinas, UNICAMP.  He joined the faculty at UNICAMP in 1992, even before finishing his Ph.D. In 1994 He moved to the United States for a postdoctoral appointment at Harvard University (1994-1995, Professor David A. Evans). Since 1992, Prof. Dias is a Professor of Organic Chemistry at The Universidade Estadual de Campinas, UNICAMP (The State University of Campinas, UNICAMP), located in the city of Campinas, state of São Paulo, Brazil.

Prof. Dias research interests are in the area of total synthesis of biologically active and structurally interesting natural products. Some of the natural products synthesized in his lab are: callystatin A, crocacin D, crocacin C, pironetin, prelactone B, spiroketal fragments of s pirofungin A and B, and the carbocyclic fragment of stawamycin. In addition, his group has completed the total synthesis of the aspartyl protease inhibitors L-682,679, L684,414, L-685,434, and L-685,458, which also present complex structures. He is also interested in the development of reactions that are relevant to the synthesis of complex organic structures. In this area, particularly relevant are the contributions regarding the use of boron enolates of methyl ketones in aldol reactions and the addition of chiral allyltrichlorostannanes to achiral and chiral aldehydes. More recently, Prof. Dias has become interested in theoretical chemistry, especially dealing with orbital interactions and their effects in conformational preferences of cyclic and acyclic systems.

 

SHORT CV – LUIZ C. DIAS

PERSONAL

Born Balneário Camboriú, SC, Brazil. Married to Luciana Gonzaga de Oliveira. Two daughters (Luana de Oliveira Dias and Luiza de Oliveira Dias)

RESEARCH INTERESTS:

Total synthesis of biologically active and structurally interesting natural products. Development of reactions that are relevant to the synthesis of complex organic structures.

EMPLOYMENT

1999-present : State University of Campinas - UNICAMP
Associate Professor – MS-5

1993-1999 : State University of Campinas - UNICAMP
Assistant Professor – MS-3

1992-1993 : State University of Campinas - UNICAMP
Instructor Professor – MS-1

EDUCATION

1994-1995 : FAPESP Postdoctoral Fellow
Harvard University, Cambridge, Massachusetts - USA.
Research advisor: Professor David A. Evans
Total synthesis of spongistatins

1988-1993 : State University of Campinas-UNICAMP, Campinas, Brazil.
Degree awarded: Ph.D.
Research advisor: Professor Ronaldo A. Pilli

1984-1988 : Federal University of Santa Catarina (UFSC)
Degree awarded: Undergraduate degree in Chemistry

 

AWARDS AND HONORS

  1. Journal of the Brazilian Chemical Society Medal (1999) - Most cited article of this Journal (Dias, L.C. J. Braz. Chem. Soc.1997, 8, 289-332).
  2. Federal University of Rio de Janeiro Medal– 40 Years of Graduate studies at UFRJ (2003).
  3. One group paper in The Top-16 Most-Accessed articles in the Journal of Organic Chemistry (2005) ( J. Org. Chem . 2005, 70, 2225-2234)

PLENARY LECTURESHIPS

  1. I Escola de Inverno de Quimica de Blumenau. FURB, Blumenau, SC, 07/2007.
  2. II Encontro Regional do Distrito Federal da Sociedade Brasileira de Química e da V Semana de Química da UCB. Brasília, DF, 06/2007.
  3. Université Catholique de Louvain – Départment de Chimie – Louvain-La-Neuve – Belgium. 02/2007.
  4. University of Basel, Switzerland. 02/2007.
  5. Institut für Organische Chemie, Leibniz Universität Hannover, Hannover, Germany. 02/2007.
  6. Department Chemie and Biochemistry, Ludwig-Maximilians-Universität, Munchen (Germany). 02/2007.
  7. Institut für Organische Chemie, Universität Regensburg. 02/2007.
  8. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz , Mülheim an der Ruhr, Germany. 02/2007.
  9. Leibniz Institute of Plant Biochemistry, Halle, Germany. 01/2007.
  10. Federal University of Rio de Janeiro - Núcleo de Pesquisas de Produtos Naturais – NPPN/RJ. 2006.
  11. Departamento de Física Aplicada. Cinvestav-IPN - Unidad Mérida. 2006.
  12. Institute of Chemistry - University of São Paulo at São Carlos. 2006.
  13. Department of Chemistry - Federal University of Santa Catarina - UFSC. 2006.
  14. The 3rd Brazilian Symposium on Medicinal Chemistry (Recent Advances in
    Drug Discovery and Development.
  15. 16th International Conference on Organic Synthesis - IUPAC ICOS 16 - (2006 - Mérida, México)
  16. The 2nd Brazilian Symposium on Medicinal Chemistry - Rio de Janeiro, Brazil, 2004
  17. Instituto do Milênio de Materiais Complexos – State University of Campinas – UNICAMP, 2004
  18. Federal University of São Carlos - UFSCar – SP, 2004
  19. Federal University of Rio de Janeiro – UFRJ, 2003
  20. 10th Brazilian Meeting on Organic Synthesis - 2003 – Brazil
  21. Federal University of Santa Catarina - UFSC – SP, 2003
  22. Federal University of Rio de Janeiro – UFRJ, 2002
  23. Federal University of Rio Grande do Sul – UFRGS, 2001
  24. Federal University of Santa Maria – UFSM, 2001
  25. 9th Brazilian Meeting on Organic Synthesis - 2001 – Brazil
  26. 9th Symposium on the Latest Trends in Organic Synthesis - Gainesville, FL, USA, 2000
  27. 23rd National Meeting of the Brazilian Chemical Society, 2000 State University of Campinas - UNICAMP, 2000
  28. State University of São Paulo – USP - SP, 1999
  29. Federal University of São Carlos - UFSCar – SP, 1999
  30. Federal University of Santa Catarina - UFSC – SP, 1996
  31. State University of Campinas - UNICAMP, 1995
  32. 15th National Meeting of the Brazilian Chemical Society, 1992

POSITIONS

  1. General Secretary of the Brazilian Chemical Society - SBQ (2000-2004)
  2. General Coordinator of the 24th (2001), 25th (2002), 26th (2003), and 27th (2004) National Meetings of the Brazilian Chemical Society
  3. General Secretary of the 8th Brazilian Meeting on Organic Synthesis (8th BMOS) (1998)
  4. Associate Editor of the Journal of the Brazilian Chemical Society (2005)
  5. Editor of the Journal of the Brazilian Chemical Society (2006-present)
  6. Editor of the Brazilian Chemical Society Bulletin (2000-2006)

SELECTED PUBLICATIONS

1. "Recent Results Towards the Stereoselective Synthesis of Biologically Active Natural Products". Dias, L.C.; de Oliveira, L.G.; Meira, P.R.R. Pure and Applied Chemistry 2007, 79, 163-172.
DOI:10.1351/pac200779020163.

2. "Chiral boron enolate aldol additions to chiral aldehydes". Dias, L.C.; Aguilar, A.M Org. Lett. 2006, 8, 4629-4632.
(DOI:10.1021/ol0618712).

3. "Spirofungins A and B: A Reassignment of Kiyota's Spiroketals". De Oliveira, L.G.; Dias, L.C.; Sakauchi, H.; Kiyota, H. Tetrahedron Letters 2006, 47, 2413-2418.

4. "Studies on the total synthesis of sanglifehrin A: stereoselective synthesis of the C(29)-C(39) fragment". Dias, L.C. and Salles Jr., A.G. Tetrahedron Letters 2006, 47, 2213-2216.

5. "A short approach to trisubstituted gamma-butyrolactones". Dias, L.C.; de Castro, I.B.D.; Steil, L.J.; Augusto, T. Tetrahedron Letters 2006, 47, 213-216.
(DOI:10.1016/j.tetlet.2005.10.151).

6. "Concerning the Application of the 1H NMR ABX Analysis for Assignment of Stereochemistry to Aldols Deriving from Aldehydes Lacking beta-Branches". Dias, L.C.; Aguilar, A.M.; Salles Jr, A.G.; Steil. L.J.; Roush, W.R. J. Org. Chem. 2005, 70, 10461-10465.
(DOI: 10.1021/jo051773e).

7. "Total synthesis of the potent antitumor polyketide (-)-callystatin A". Dias, L.C. Meira, P.R.R. J. Org. Chem. 2005, 70, 4762-4773.
(DOI:10.1021/jo050352u).

8. "Total synthesis of (+)-crocacin D". Dias, L.C.; de Oliveira, L.G.; Vilcachagua, J.D.; Nigsch, F. J. Org. Chem. 2005, 70, 2225-2234.
(DOI: 10.1021/jo047732k).

9. "A short approach to the bicyclo[4.3.0]nonane fragment of stawamycin". Dias, L.C.; Melgar, G.Z.; Jardim, L.S.A. Tetrahedron Letters 2005, 46, 4427-4431.
(DOI:10.1016/j.tetlet.2005.05.004 ).

10. "Orbital interactions and their effects on conformational preferences for 4,6-disubstituted-2,2-dimethyl-1,3-dioxanes. A theoretical study". Tormena, C.F.; Dias, L.C.; Rittner, R J. Phys. Chem. A. 2005, 109, 6077-6082.
(DOI: 10.1021/jp052048a).

11. "Short Synthesis of the 6,6-Spiroketal Cores of Spirofungin A and B". Dias, L.C.; de Oliveira, L. G. Organic Letters 2004, 6, 2587-2590.
(DOI: 10.1021/ol0491078).

12. "Addition of Lactate-derived Chiral Allyltrichlorostannanes to Chiral Aldehydes". Dias, L. C. and Steil, L. J. Tetrahedron Letters 2004, 45, 8835-884.

13. "A Short and Efficient Synthesis of (+)-Prelactone B". Dias, L. C.; Steil, L. J.; Vasconcelos, V. A. Tetrahedron: Asymmetry 2004, 15, 147-150.

14. Feature Article: "Allyltrichlorostannane Additions to alpha-Aminoaldehydes. Application to the Total Synthesis of the Aspartyl Protease Inhibitors L-682,679, L684,414, L-685,434, and L-685,458".. Dias, L.C.; Diaz, G.; Ferreira, A.A.; Meira, P.R.R.; Ferreira, E. Synthesis 2003, 4, 603-622.

15. Total Synthesis of (-)-Pironetin". Dias, L.C.; de Oliveira, L.G.; Sousa, M.A. Organic Letters 2003, 5, 265-268.
(DOI: 10.1021/ol027211o).

16. High 1,5-anti stereoinduction in boron-mediated aldol reactions of methyl ketones" . Luiz C. Dias, Rosana Z. Baú, Márcio A. de Sousa and J. Zukerman-Schpector Organic Letters 2002, 4, 4325-4327.
(DOI: 10.1021/ol026968c).

17. "Synthesis of C1-C11 Fragment of Callystatin A". Dias, L. C.; Meira, P. R. R. Tetrahedron Letters 2002, 43, 8883-8885.

18. "Total Synthesis of (+)-Crocacin C". Dias, L.C. and de Oliveira, L.G. Organic Letters 2001, 3, 3951-3954.
(DOI: 10.1021/ol016845c).

19. "Allyltrichlorostannane Additions to Chiral Dipeptide Aldehydes". Dias, L.C.; Ferreira, E. Tetrahedron Letters 2001, 42, 7159-7162.

20. "NMR Study on Ligand Exchange Reaction Between a Chiral Allylsilane and SnCl4". Luiz C. Dias*; Paulo R.R. Meira; Edílson Ferreira Organic Letters 1999, 1(9), 1335-1338.


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