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Concluded Synthesis


(+)-Crocacin C

The crocacins A-D are a group of compounds which are regularly found in the extracts of the Chondromyces crocatus strain and Chondromyces pediulatus and represent a second novel group of modified peptides from C. crocatus. Crocacin C is a structure fragment Crocacin D. The crocacins moderately inhibit the growth of a few gram-positive bacteria and are potent inhibitors of animal cell cultures and several yeasts and fungi. Crocacin D shows higher biological activity against Saccharomyces cerevisiae as well as higher toxicity in L929 mouse fibroblast cell culture when compared to crocacins A-C.

  1. "Total Synthesis of (+)-Crocacin C". Dias, L.C. and de Oliveira, L.G. Organic Letters 2001, 3, 3951-3954.


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