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Concluded Synthesis

 

L-685,434: HIV-1 protease Inhibitor

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L-685,434 (1) is a potent HIV-1 protease inhibitor (IC 50 = 0.23 nM) containing 1-(S)-amino-2-(R)-hydroxyindan P 2’ ligand. This inhibitor was found to block the spread of HIV-1 in T-lymphoid cells, being a highly potent and selective HIV protease inhibitor.

 

  1. "Allyltrichlorostannane Additions to alpha-Aminoaldehydes. Application to the Total Synthesis of the Aspartyl Protease Inhibitors L-682,679, L684,414, L-685,434, and L-685,458". Dias, L.C.; Diaz, G.; Ferreira, A.A.; Meira, P.R.R.; Ferreira, E. Synthesis 2003, 4, 603-622.

  2. "Short Total Synthesis of Aspartyl Protease Inhibitors L-685,434, L-682,679 and L-685,458", Dias, L.C, Ferreira, A.A. and Diaz, Gaspar. Synlett 2002, 1845-1849.

 

 

 

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