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Concluded Synthesis


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Methylphenidate (Ritalin): Treatment of Attention Deficit Hyperactivity Disorders

Methylphenidate hydrochloride (Ritalin, 2RS,3RS- a -phenyl-2-piperidineacetic acid methyl ester hydrochloride) is a commonly prescribed mild nervous system stimulant used in the treatment of Attention Deficit Hyperactivity Disorders (ADHD) in children and used for the treatment of narcolepsy and depression in adults. Methylphenidate is a dopamine reuptake blocker with stimulant properties that was first synthesized more than 50 years ago. The stimulant properties reside in the threo isomer and Methylphenidate is administered to patients as a racemic mixture of threo diastereomers. It has also been reported that a mixture of racemic threo and erythro-methylphenidate can be epimerized to pure threo racemates.


Dias, L. C.; Fernandes, A. M. A. P.

Synthethic Communications 2000, 3, 3951-3954

Patent number: BR9903436-A: "Synthesis of methyl phenidate consists of preparation of erythro isomers and methoxy and other derivatives".

Publication Date: 13 March 2001 . Use: In Industrial Chemistry


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